Major mathematical hurdles for biomarker-based screening
نویسندگان
چکیده
منابع مشابه
The probability of indicating Osteoprotegrin as a biomarker for osteoporosis in patient with thalassemia major
Background: Osteoporosis is one of the main causes of morbidity in patients with thalassemia major. Osteoprotegerin (OPG) is secreted by osteoblasts and osteogenic stromal stem cells and protects the skeleton from excessive bone reabsorption. In this study, the authors aimed to assess the relationship between OPG with osteoporosis and osteopenia in patients with thalassemia major. Materials an...
متن کاملMicroarray screening for novel preeclampsia biomarker candidates.
INTRODUCTION Our aim was to identify novel biomarker candidates for the near-term prediction of preeclampsia in a homogenous collective. In this study, we screened at the genome-wide level for gene expression in placental villous tissue from patients with severe preeclampsia in comparison to normal healthy pregnancies. MATERIAL AND METHODS Total RNA was extracted from placental villous tissue...
متن کاملHigh-Throughput Screening for Biomarker Discovery
1Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand 2Graduate School of Science and Engineering, Yamaguchi University, Yamaguchi 753-8511, Japan 3Department of Veterinary & Biomedical Sciences, College of Agriculture & Biological Sciences, South Dakota State University, Brookings, SD 57006, USA 4Center of Infectious Disease and Signaling Research, Nation...
متن کاملHigh throughput proteome screening for biomarker detection.
Mass spectrometry-based quantitative proteomics has become an important component of biological and clinical research. Current methods, while highly developed and powerful, are falling short of their goal of routinely analyzing whole proteomes mainly because the wealth of proteomic information accumulated from prior studies is not used for the planning or interpretation of present experiments. ...
متن کاملNon-biological gene carriers designed for overcoming the major extra- and intracellular hurdles in gene delivery, an updated review
Gene therapy as a modern therapeutic approach has not yet advanced to a globally-approved therapeutic approach. Lack of adequate reliable gene delivery system seems to be one of the major reasons from the pharmaceutical biotechnology point of view. Main obstacles delaying successful application of human gene therapy are presented in this review. The unique advantages of non-biological gene carr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2011
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc3191